Rulicent is approved for the treatment of several hematologic and immune-mediated conditions in adults and selected pediatric populations:
Pregnancy: There is no conclusive evidence from human studies. Rulicent should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Breastfeeding: Unknown if excreted in human milk. Discontinue breastfeeding during treatment and for at least two weeks after the last dose due to potential infant exposure.
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Ruxolitinib is an oral selective inhibitor of Janus-associated kinases (JAK1 and JAK2)—enzymes critical for signal transduction from cytokine and growth factor receptors involved in blood cell production and immune regulation.
In myelofibrosis, a condition marked by uncontrolled JAK signaling, Ruxolitinib corrects dysregulation by:
Route: Oral
Administration: Can be taken with or without food. If a dose is missed, resume with the next scheduled dose without doubling.
Dosing is based on baseline platelet count:
≥200 × 10⁹/L: 20 mg twice daily
100–199 × 10⁹/L: 15 mg twice daily
50–99 × 10⁹/L: 5 mg twice daily
Frequent monitoring (CBC every 2–4 weeks) is required to guide dose adjustments.
Starting dose: 10 mg twice daily
Consider reducing to 5 mg twice daily if hemoglobin is between 8–12 g/dL or platelets fall below 75 × 10⁹/L.
Initial dose: 5 mg twice daily
May increase to 10 mg twice daily after 3 days if ANC and platelet counts remain stable.
- Pediatric Use: Approved for acute GVHD in patients aged 12 years and older. Not established for other indications.
- Elderly: No specific dose adjustments, but greater susceptibility to adverse effects like infections and cytopenias may require cautious use.
No specific antidote exists.
Single doses up to 200 mg have been tolerated; repeated high doses may cause significant myelosuppression (low WBC, RBC, and platelets).
Supportive measures are recommended. Hemodialysis is ineffective in drug clearance.
Common adverse effects include:
Hematologic: Thrombocytopenia, anemia, neutropenia
General: Headache, dizziness, bruising
Infectious risk: Opportunistic bacterial, fungal, and viral infections
Discontinuation symptoms: Disease rebound, including fever, hypotension, respiratory distress
Skin cancers: Reports of non-melanoma skin cancers (e.g., basal cell, squamous cell, Merkel cell carcinoma)
Fluconazole (>200 mg/day): Inhibits Ruxolitinib metabolism via CYP3A4/CYP2C9, increasing drug levels. Avoid high doses of fluconazole except in acute GVHD.
Strong CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole): Elevate Ruxolitinib exposure. Reduce the Rulicent dose and monitor blood counts closely.
Strong CYP3A4 Inducers: May lower drug levels; frequent monitoring is recommended to adjust dose based on clinical response.
Patients with known hypersensitivity to Ruxolitinib or any formulation component must avoid this medication.
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.