Rulicent 10 | 1 Strip | 7pcs Tablet
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Rulicent 10 | 1 Strip | 7pcs Tablet

Generic: Ruxolitinib

Type: Tablet

Pack Size: 7pcs

Rulicent is approved for the treatment of several hematologic and immune-mediated conditions in adults and selected pediatric populations:

  • Myelofibrosis (MF): Rulicent is used in adults diagnosed with intermediate to high-risk MF, including primary myelofibrosis, post-polycythemia vera MF, and post-essential thrombocythemia MF, to manage disease progression and related symptoms.
  • Polycythemia Vera (PV): Indicated for adult patients with PV who either do not respond adequately to hydroxyurea or are intolerant to its side effects.
  • Steroid-Refractory Acute Graft-versus-Host Disease (GVHD): Approved for adults and pediatric patients aged 12 years and older with acute GVHD that does not respond to corticosteroid treatment.

Pregnancy: There is no conclusive evidence from human studies. Rulicent should be used during pregnancy only if the potential benefit justifies the risk to the fetus.

Breastfeeding: Unknown if excreted in human milk. Discontinue breastfeeding during treatment and for at least two weeks after the last dose due to potential infant exposure.

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✅ Description:

Ruxolitinib is an oral selective inhibitor of Janus-associated kinases (JAK1 and JAK2)—enzymes critical for signal transduction from cytokine and growth factor receptors involved in blood cell production and immune regulation.

In myelofibrosis, a condition marked by uncontrolled JAK signaling, Ruxolitinib corrects dysregulation by:

  • Suppressing splenomegaly (enlarged spleen)
  • Reducing mutant JAK2V617F allele burden
  • Lowering circulating inflammatory cytokines (e.g., TNF-α, IL-6)

Pharmacokinetics Overview:

  • Absorption: Rapidly absorbed after oral administration; peak levels (Cmax) achieved within 1–2 hours.
  • Bioavailability: Oral absorption is at least 95%.
  • Distribution: Steady-state volume of distribution ~72 L.
  • Plasma Protein Binding: ~97%, primarily to albumin.
  • Metabolism: Predominantly via CYP3A4, with minor involvement of CYP2C9.
  • Elimination Half-Life: ~3 hours (drug); ~5.8 hours (with metabolites).
  • Excretion: Primarily through metabolism—74% in urine, 22% in feces; <1% excreted as unchanged drug.
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✔️ Dosage and Administration | Rulicent 10

Route: Oral
Administration: Can be taken with or without food. If a dose is missed, resume with the next scheduled dose without doubling.

For Myelofibrosis (MF):

Dosing is based on baseline platelet count:

≥200 × 10⁹/L: 20 mg twice daily

100–199 × 10⁹/L: 15 mg twice daily

50–99 × 10⁹/L: 5 mg twice daily

Frequent monitoring (CBC every 2–4 weeks) is required to guide dose adjustments.

For Polycythemia Vera (PV):

Starting dose: 10 mg twice daily

Consider reducing to 5 mg twice daily if hemoglobin is between 8–12 g/dL or platelets fall below 75 × 10⁹/L.

For Acute GVHD:

Initial dose: 5 mg twice daily

May increase to 10 mg twice daily after 3 days if ANC and platelet counts remain stable.

  • Pediatric Use: Approved for acute GVHD in patients aged 12 years and older. Not established for other indications.
  • Elderly: No specific dose adjustments, but greater susceptibility to adverse effects like infections and cytopenias may require cautious use.
✔️ Overdose Management | Rulicent 10

No specific antidote exists.

Single doses up to 200 mg have been tolerated; repeated high doses may cause significant myelosuppression (low WBC, RBC, and platelets).

Supportive measures are recommended. Hemodialysis is ineffective in drug clearance.

✔️ Side Effects | Rulicent 10

Common adverse effects include:

Hematologic: Thrombocytopenia, anemia, neutropenia

General: Headache, dizziness, bruising

Infectious risk: Opportunistic bacterial, fungal, and viral infections

Discontinuation symptoms: Disease rebound, including fever, hypotension, respiratory distress

Skin cancers: Reports of non-melanoma skin cancers (e.g., basal cell, squamous cell, Merkel cell carcinoma)

✔️ Drug Interactions

Fluconazole (>200 mg/day): Inhibits Ruxolitinib metabolism via CYP3A4/CYP2C9, increasing drug levels. Avoid high doses of fluconazole except in acute GVHD.

Strong CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole): Elevate Ruxolitinib exposure. Reduce the Rulicent dose and monitor blood counts closely.

Strong CYP3A4 Inducers: May lower drug levels; frequent monitoring is recommended to adjust dose based on clinical response.

✔️ Contraindications

Patients with known hypersensitivity to Ruxolitinib or any formulation component must avoid this medication.

✔️ Precautions & Warnings
  • Bone Marrow Suppression: Monitor CBCs regularly. Thrombocytopenia may require dose reduction or drug interruption. Severe neutropenia is usually reversible upon drug cessation.
  • Serious Infections: Delay treatment until active infections are resolved. Monitor throughout therapy.
  • Tuberculosis (TB): Screen for TB risk before initiation. Treat latent TB prior to Rulicent initiation if required.
  • Progressive Multifocal Leukoencephalopathy (PML): A rare but serious brain infection; discontinue immediately if suspected.
  • Herpes Zoster: Educate patients about signs and encourage early medical attention.
  • Hepatitis B Reactivation: Regular HBV monitoring is advised in patients with chronic HBV.
  • Discontinuation Reactions: Sudden withdrawal may lead to disease flare, systemic symptoms, and serious complications. Taper gradually if feasible.
  • Skin Cancer: Conduct periodic skin assessments during long-term use.
  • Lipid Monitoring: Check cholesterol and triglyceride levels 8–12 weeks after starting therapy. Manage according to guidelines.
  • Store at below 30°C in a dry, light-protected place.
  • Keep out of reach of children.
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